4668株呼吸道感染病原菌的耐药性研究

发布时间：2018-01-04 21:35

本文关键词：4668株呼吸道感染病原菌的耐药性研究　出处：《现代预防医学》2016年01期 　论文类型：期刊论文

【摘要】：目的了解医院呼吸道感染病原菌的分布及耐药性,为临床合理用药提供依据。方法收集2012-2014年送检的29352例痰液和咽拭子标本,采用VITEK-2 Compact辅以K-B纸片法对病原菌进行鉴定和药敏试验,采用WHONET5.6进行分析。结果共分离出4668株病原菌,革兰阴性杆菌占72.1%,革兰阳性球菌占27.9%;检出率前5位的菌依次是铜绿假单胞菌、大肠埃希菌、肺炎克雷伯菌、金黄色葡萄球菌和鲍曼不动杆菌。MRSA检出率为56.1%,产ESBLs的大肠埃希菌和肺炎克雷伯菌检出率为34.8%和15.1%。多重耐药鲍曼不动杆菌分离率为44.7%。铜绿假单胞菌和鲍曼不动杆菌对多粘菌素、阿米卡星的耐药率低;大肠埃希菌和肺炎克雷伯菌对亚胺培南和美洛培南100%敏感,对阿米卡星耐药率均5%;未发现耐万古霉素和替考拉宁的金黄色葡萄球菌。MRSA对所有药物的耐药性均高于MSSA,其中5种药物的耐药率经分析差异有统计学意义(P0.01)。结论医院呼吸道分离菌以革兰阴性杆菌为主,应重视对细菌的耐药性监测,以促进临床合理用药。
[Abstract]:Objective to investigate the distribution and drug resistance of pathogens causing respiratory tract infection in hospital, provide the basis for clinical rational drug use. Methods 29352 cases of sputum collected during 2012-2014 inspection and throat swab specimens by VITEK-2 Compact and K-B method for identification and drug susceptibility testing of pathogens, were analyzed by WHONET5.6. Results a total of 4668 strains of pathogens isolated, gram negative bacilli accounted for 72.1%, gram positive cocci accounted for 27.9%; the detection rate of the top 5 of the bacteria were Pseudomonas aeruginosa, Escherichia coli, Klebsiella Lei Bojun, Staphylococcus aureus and Bauman Acinetobacter.MRSA positive rate was 56.1%, Escherichia coli and Klebsiella pneumoniae ESBLs the detection rate was 34.8% and the 15.1%. of multi drug resistant Acinetobacter Bauman 44.7%. isolation rate of Pseudomonas aeruginosa and Acinetobacter Bauman to polymyxin, Amikacin's low rate of resistance; Escherichia coli and Klebsiella pneumoniae Strains to imipenem and meropenem were 100% sensitive, 5% on the Amikacin resistance rate;.MRSA was not found in Staphylococcus aureus resistant to vancomycin and teicoplanin were higher than that of MSSA resistance to all drugs, the drug resistance rate of 5 drugs through the analysis of the difference was statistically significant (P0.01). Conclusion nosocomial respiratory tract pathogens were gram negative bacilli, attention should be paid to the monitoring of drug resistance of bacteria, promote clinical rational drug use.

【作者单位】：成都医学院检验医学院临床微生物教研室;重庆市万州区人民医院检验科;成都医学院结构特异性小分子药物研究实验室;
【基金】：四川省科技厅应用基础研究项目(2009JY0120) 国家自然科学基金资助项目(81373454)
【分类号】：R446.5
【正文快照】： 呼吸道感染是最常见的感染性疾病,随着我国空气质量的下降和人口老龄化,临床呼吸道感染疾病益发常见。随着地域、时期和用药习惯的不同,各地医院分离出的呼吸道感染病原菌分布及耐药性也呈现多样性,并且多重耐药和泛耐药菌株不断出现,给临床带来了十分棘手的难题[1]。因此长期

【相似文献】