脑梗死患者骨代谢指标的变化及危险因素分析

发布时间：2018-03-03 03:24

本文选题：羟基维生素D　切入点：甲状旁腺素　出处：《广东医学》2016年18期 　论文类型：期刊论文

【摘要】：目的探讨25羟基维生素D[25-(OH)D]、甲状旁腺素(PTH)、骨源性碱性磷酸酶(BALP)、骨钙素(OC)浓度与脑梗死发生的关系。方法选取65例脑梗死患者、46例脑出血患者、39例脑外伤患者、12例脑肿瘤患者为观察组及同期该院体检科45例健康体检者为对照组,采用电化学发光法(ECLIA)检测血清25-(OH)D、PTH、BALP、OC水平,并对结果进行统计分析。结果脑梗死组25-(OH)D水平明显低于对照组(P0.01),并且脑梗死、脑外伤组25-(OH)D浓度分类中,缺少水平显著高于对照组(P0.05),脑梗死组PTH、BALP、OC水平显著高于对照组(P0.05);脑出血组25-(OH)D、PTH、OC与对照组差异有统计学意义(P0.05);脑外伤组PTH、BALP、OC水平显著低于脑梗死组(P0.05)。脑肿瘤组仅血清25-(OH)D、OC与对照组差异有统计学意义;脑梗死患者25-(OH)D水平与PTH有明显相关性(P0.05),与BALP、OC无相关性。结论低25-(OH)D、高PTH、高BALP、高OC为脑梗死的危险因素,适量补充25-(OH)D,降低PTH、BALP、OC水平可能是预防和治疗脑梗死的有效手段。
[Abstract]:Objective to investigate the relationship between the concentrations of 25 hydroxyvitamin D, PTH, osteogenic alkaline phosphatase (BALP), osteocalcin (OC) and cerebral infarction. Methods Sixty-six patients with cerebral infarction, 46 patients with cerebral hemorrhage, 39 patients with cerebral trauma and 12 patients with brain injury were selected. The tumor patients in the observation group and 45 healthy persons in the same period were the control group. ECLIA was used to detect the level of BALPHOOC in patients with cerebral infarction, and the results were statistically analyzed. Results the level of 25-OHHfD in the cerebral infarction group was significantly lower than that in the control group (P 0.01), and in the classification of 25-OHH D concentration in the cerebral infarction and traumatic brain injury group, there was no significant difference between the two groups. The level of P0.05a in cerebral infarction group was significantly higher than that in control group (P 0.05), and that in cerebral infarction group was significantly higher than that in control group (P0.05), there was a significant difference between cerebral hemorrhage group and control group (P 0.05), and the level of PTHmb BALPNOC in brain injury group was significantly lower than that in cerebral infarction group (P 0.05). The difference of control group was statistically significant. Conclusion low 25-OHH, high BALP, high BALP, and high OC are the risk factors of cerebral infarction. It may be an effective method to prevent and treat cerebral infarction by adding appropriate amount of 25-OHH and decreasing the level of PTH.
【作者单位】：南昌大学第二附属医院检验科;南昌大学第二临床医学院;
【基金】：江西省教育厅学位与研究生教育改革研究项目(编号:9162-2205000301)
【分类号】：R743.3;R446.1

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