新型多季铵盐类抗菌剂的合成及其抗菌活性研究

发布时间：2018-05-16 19:45

本文选题：季铵盐 + 抗菌剂　；参考：《现代化工》2016年12期

【摘要】：以4,4'-二氨基二苯甲烷四缩水甘油胺为原料,通过两步法合成制备了一系列不同季铵化度(20%、40%、60%、80%、100%)的多季铵盐抗菌剂,利用红外、核磁共振氢谱对其进行分析和表征,并测定其临界胶束浓度(CMC)、临界表面张力(γCMC)、最小抑菌浓度(MIC)、最小杀菌浓度(MBC)等。研究结果表明,随着季铵化度的增大,临界胶束浓度和临界表面张力减小,抗菌性增强,且都优于常规型抗菌剂十二烷基二甲基苄基氯化铵。季铵化度为100%的多季铵盐B-100的CMC为10.22 g/L,γCMC为29.46 m N/m,对金色葡萄球菌的MIC为7.813μg/m L,对大肠杆菌的MIC为15.625μg/m L,对金色葡萄球菌的MBC为15.625μg/m L,对大肠杆菌的MBC为31.25μg/m L。该抗菌剂可应用于织物、地板、卫生间、家电、汽车等抗菌装饰材料。
[Abstract]:A series of multi-quaternary ammonium salt antimicrobial agents with different degrees of quaternary ammonium were synthesized by two-step method from 4C4N -diaminodiphenylmethane tetraglycidylamine. The antimicrobial agents of multi-quaternary ammonium salt were analyzed and characterized by infrared and nuclear magnetic resonance hydrogen spectra. The critical micelle concentration (CMC), the critical surface tension (纬 CMC), the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined. The results show that the critical micelle concentration and critical surface tension decrease with the increase of the degree of quaternary ammonium, and the antibacterial activity is enhanced, which is superior to that of the conventional antibacterial agent dodecyl dimethyl benzyl ammonium chloride. The CMC of multiquaternary ammonium salt B-100 was 10.22 g / L, 纬 CMC was 29.46 mm / m, MIC for Staphylococcus aureus was 7.813 渭 g / mL, MIC for Escherichia coli was 15.625 渭 g / m L, MBC for Staphylococcus aureus was 15.625 渭 g / m L, MBC for Escherichia coli was 31.25 渭 g / mL. The antibacterial agent can be used in fabric, floor, toilet, household appliances, automobile and other antibacterial decorative materials.
【作者单位】：广州大学化学化工学院;
【基金】：国家自然科学基金(21303026) 广东省自然科学基金(2015A030313506) 广东省科技计划项目(2014A010105052) 广州市科技计划项目(201510010131) 广州市南沙区科技计划项目(2015KF001)
【分类号】：TB34

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