胶原蛋白海绵对肝脏创伤止血的效果
发布时间：2018-12-18 00:29
【摘要】：背景:艾瑞金胶原蛋白海绵理化性能稳定,并已通过国家食品药品监督管理局的理化性能和生物相容性评价检测。目的:观察艾瑞金胶原蛋白海绵的止血效果。方法:取21只SD大鼠,建立肝脏出血创面,随机分3组干预:在实验组(n=7)肝脏创口内部植入艾瑞金胶原蛋白海绵,同时在肝脏切口表面外敷艾瑞金胶原蛋白海绵;在阳性对照组(n=7)肝脏创口内部植入医用胶原蛋白海绵,同时在肝脏切口表面外敷医用金胶原蛋白海绵;在空白对照组(n=7)肝脏切口表面外敷医用纱布,记录出血量及止血时间,干预后7,14,28 d进行肝脏创面组织学观察。结果与结论:①出血量及止血时间:3组出血量比较无差异;实验组、阳性对照组止血时间与空白对照组比较差异无显著性意义,实验组止血时间短于阳性对照组(P≤0.05);②肝脏创面组织学观察:实验组干预后7 d胶原材料被纤维结缔组织完全包裹,炎性细胞浸润以中性粒细胞为主,胶原材料开始降解,周边结缔组织内有新生毛细血管;干预后14 d,包裹胶原材料的纤维结缔组织明显增厚,中性粒细胞减少,巨噬细胞增多;干预后28 d,胶原材料完全降解,大部肝组织恢复正常,部分肝组织旁的炎性结缔组织中可看到巨噬细胞、单核细胞、成纤维细胞和毛细血管。阳性对照组情况类似于实验组。空白对照组干预后14 d创伤处结缔组织明显,肝窦含有红细胞,偶见肝组织内出血,空泡变性;干预后28 d,创口处具有较厚结缔组织,肝窦含有红细胞,被复肝星状细胞;③结果表明:艾瑞金胶原蛋白海绵对肝脏创伤止血效果明显,组织相容性好。
[Abstract]:Background: the physical and chemical properties of Irikin collagen sponge are stable and have been evaluated by the State Food and Drug Administration (SFDA). Objective: to observe the hemostatic effect of irizine collagen sponge. Methods: 21 SD rats were randomly divided into 3 groups: in the experimental group (n = 7), intrahepatic collagen sponge was implanted into the liver wound, and the surface of the hepatic incision was coated with the iritin collagen sponge. Medical collagen sponge was implanted into the hepatic wound of the positive control group (nong7), and the medical gold collagen sponge was applied on the surface of the hepatic incision at the same time. Medical gauze was applied on the surface of the hepatic incision in the blank control group (nong7). The amount of bleeding and the hemostatic time were recorded. The histological observation of the liver wound was carried out on the 28th day after intervention. Results and conclusion: 1 bleeding volume and hemostatic time: there was no difference in bleeding volume among the three groups. There was no significant difference in hemostatic time between the positive control group and the blank control group. The hemostasis time in the experimental group was shorter than that in the positive control group (P 鈮，
本文编号：2385011
[Abstract]:Background: the physical and chemical properties of Irikin collagen sponge are stable and have been evaluated by the State Food and Drug Administration (SFDA). Objective: to observe the hemostatic effect of irizine collagen sponge. Methods: 21 SD rats were randomly divided into 3 groups: in the experimental group (n = 7), intrahepatic collagen sponge was implanted into the liver wound, and the surface of the hepatic incision was coated with the iritin collagen sponge. Medical collagen sponge was implanted into the hepatic wound of the positive control group (nong7), and the medical gold collagen sponge was applied on the surface of the hepatic incision at the same time. Medical gauze was applied on the surface of the hepatic incision in the blank control group (nong7). The amount of bleeding and the hemostatic time were recorded. The histological observation of the liver wound was carried out on the 28th day after intervention. Results and conclusion: 1 bleeding volume and hemostatic time: there was no difference in bleeding volume among the three groups. There was no significant difference in hemostatic time between the positive control group and the blank control group. The hemostasis time in the experimental group was shorter than that in the positive control group (P 鈮，
本文编号：2385011
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