羌独康膝颗粒治疗膝骨性关节炎（风寒湿痹证）的临床研究

发布时间：2017-12-31 18:39

本文关键词：羌独康膝颗粒治疗膝骨性关节炎（风寒湿痹证）的临床研究　出处：《湖南中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:本课题设计之目的在于通过观察羌独康膝颗粒对膝骨性关节炎风寒湿痹证治疗效果的临床观察,全面评价羌独康膝颗粒治疗膝骨关节炎风寒湿痹证的临床疗效和安全性。方法:观察2015年2月至2015年12月期间湖南中医药大学第二附属医院骨伤二科门诊符合膝骨性关节炎(风寒湿痹证)诊断的患者60例,将60例本病患者随机分两组,一组为试验组30例,给予羌独康膝颗粒治疗;另一组为对照组30例,给予寒湿痹颗粒治疗,共21天。以治疗前和治疗后的主要症状及客观体征的变化作为观察指标,从而对两组患者的临床疗效进行观察和对比,同时检测肝肾功能等安全性指标。结果:临床研究结果表明,两组患者在治疗前组间情况经统计学比较无统计学意义(P0.05),两组患者在治疗21天后,两组组内比较显示两种药物治疗后均能有效改善患者症状,差异具有统计学意义(P0.05),两组患者在治疗21天后组间治疗效果情况比较差异无统计学意义(P0.05)。结论:羌独康膝颗粒和寒湿痹颗粒对风寒湿痹证膝骨性关节炎治疗均有肯定的疗效。两组都未发现不良反应。
[Abstract]:Objective: the purpose of this project design is to observe the clinical effect of Qiang Dukang knee granule on the treatment of rheumatic arthritis of knee osteoarthritis with wind-cold and dampness arthralgia syndrome. Objective: to evaluate the clinical efficacy and safety of Qiang Dukang knee granules in the treatment of knee osteoarthritis with the syndrome of wind-cold dampness and arthralgia. To observe that from February 2015 to December 2015, the outpatient clinic of the second affiliated Hospital of Hunan University of traditional Chinese Medicine (Hunan University of traditional Chinese Medicine) was in accordance with knee osteoarthritis (. 60 cases were diagnosed as wind cold and dampness arthralgia syndrome. 60 patients were randomly divided into two groups: the experimental group (n = 30) was treated with Qiang Dukang knee granules. The other group, 30 cases in control group, were treated with Hanshinbi granule for 21 days. The changes of main symptoms and objective signs before and after treatment were taken as the observation index. Thus the clinical efficacy of the two groups were observed and compared, and the safety indexes such as liver and kidney function were detected. Results: the clinical results showed that. There was no statistical significance between the two groups before treatment P0.05. After 21 days of treatment, the comparison between the two groups showed that the two drugs can effectively improve the symptoms of the patients. The difference was statistically significant (P0.05). There was no significant difference in therapeutic effect between the two groups after 21 days of treatment (P 0.05). Conclusion: Qiang Dukang knee granule and Hanshi Bi granule have definite curative effect on rheumatic and dampness arthralgia knee osteoarthritis, and no adverse reactions were found in both groups.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R274.9

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