辣椒素酯合成实验
发布时间：2018-08-21 11:48
【摘要】：以6-溴己酸为起始原料,利用Wittig反应,制备以Z-8-甲基-6-壬烯酸为主的产物,然后在NaNO2—HNO3的作用下,转化为以E-8-甲基-6-壬烯酸为主的产物,经后处理得到E-8-甲基-6-壬烯酸。在酶催化作用下,E-8-甲基-6-壬烯酸选择性地与香草醛的醇羟基反应,得到辣椒素酯。实验过程让学生灵活应用知识、科学组合,更加贴近真实的药物研发过程,提高了学生的学习兴趣。
[Abstract]:Using 6-bromohexanoic acid as the starting material, Z-8-methyl-6-nonenoic acid was prepared by Wittig reaction, and then transformed into E-8-methyl-6-nonenoic acid under the action of NaNO2-HNO3. E-8-methyl-6-nonenoic acid was obtained by post-treatment. Capsaicin ester was obtained by the selective reaction of E-8-methyl-6-azelenoic acid with the hydroxyl alcohol of vanillin. The experimental process allows students to apply knowledge flexibly, scientific combination, closer to the real process of drug development, and enhance students' interest in learning.
【作者单位】： 武汉大学药学院;
【基金】：国家自然科学基金项目(21402144) 武汉大学教学研究项目(2017JG056)
【分类号】：G642;TQ460.6-4
本文编号：2195620
[Abstract]:Using 6-bromohexanoic acid as the starting material, Z-8-methyl-6-nonenoic acid was prepared by Wittig reaction, and then transformed into E-8-methyl-6-nonenoic acid under the action of NaNO2-HNO3. E-8-methyl-6-nonenoic acid was obtained by post-treatment. Capsaicin ester was obtained by the selective reaction of E-8-methyl-6-azelenoic acid with the hydroxyl alcohol of vanillin. The experimental process allows students to apply knowledge flexibly, scientific combination, closer to the real process of drug development, and enhance students' interest in learning.
【作者单位】： 武汉大学药学院;
【基金】：国家自然科学基金项目(21402144) 武汉大学教学研究项目(2017JG056)
【分类号】：G642;TQ460.6-4
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