挤出滚圆法制备球形颗粒的一些关键技术的研究

发布时间：2018-05-10 08:55

本文选题：挤出滚圆 + 载药量　；参考：《华东理工大学》2010年博士论文

【摘要】： 使用挤出滚圆技术制备球形颗粒,具有生产效率高,产品圆整度好和机械性能高等特点；并且生产过程健康环保,制备工艺、设备简单,近半个世纪以来,在国内外医药、食品、饲料、化妆品等行业得到了广泛的应用。尽管挤出滚圆法造粒技术显示了巨大的优越性而被广泛的应用,但是仍然还有一些关键性问题没有解决。本文针对物料适宜挤出滚圆法造粒的理想润湿混合黏-塑态的构建问题,采用颗粒制备对比实验和机理分析相结合的方法,通过对中药鼻炎康干浸膏物料降粘方法和无机氧化铝物料增粘方法的研究,深入分析了中药浸膏物料吸湿黏结的机理、无机氧化铝球形催化剂载体制备过程中操作参数的改变对产品催化性能和表观质量的影响,为实现挤出滚圆法造粒技术在更广泛的领域应用提供理论基础。论文的主要研究工作和创新成果如下： (1)基础理论研究。分析了水与微晶纤维素润湿机理。从氢键作用、范德华力作用、分子扩散自粘作用等角度探讨了分子问不同作用力与理想润湿混合体系黏度的关系。分析了破断过程中动能向表面能的转化机理,推导出摩擦底盘转数和物料长度与物料破断效果之间内在关系的破断势能公式。通过运动模型和颗粒受力分析模型的建立,系统分析了滚圆过程中,物料总体的运动规律、单个颗粒的运动形式和颗粒滚圆成球的主要变形力,并对起主要作用的变形力进行了定量分析。 (2)提高中药浸膏微丸载药水平的研究。分析了水与中药浸膏的润湿过程、乙醇与中药浸膏的润湿过程,从配位化学键作用、静电作用和氢键过度缔合作用等角度讨论了中药浸膏物料的吸湿黏结机理。通过中药-β-环糊精包合物制备实验、中药鼻炎康浸膏微丸的制备实验与比较法黏度测定装置的研制,对比研究了各种有针对性的降粘方法中辅料的用量,在有效降低体系黏度的同时,达到了适度减少辅料用量的目标。 (3)无机粉体氧化铝适宜挤出滚圆造粒的粘-塑性体系构建。通过颗粒制备实验,筛选出无机氧化铝粉体实现挤出滚圆过程必备的最佳黏结剂、助挤剂、赋形剂。通过对有机胶黏剂与无机粉体颗粒表面的黏结机理分析和应用、偶联剂改性机理分析和应用,在制备出球形氧化铝基催化剂载体的基础上,进一步研究了提高产品圆整度和强度的措施、造粒过程及工艺参数改变对最终产品性能和表观质量的影响。 (4)有极端黏度表现物料的造粒实践。本文以本实验室自行研制的专利产品微丸造粒机为主要实验设备,以鼻炎康浸膏粉体为高黏有机物料代表,超细氧化铝粉体为低黏无机物料的典型代表,通过颗粒制备实验确定了最佳造粒配方和工艺操作参数,并重点讨论了球形氧化铝催化剂载体制备过程对催化剂载体性能的影响。
[Abstract]:The spherical particles prepared by extrusion round technology have the characteristics of high production efficiency, good product roundness and high mechanical properties, and the production process is healthy and environmental friendly, the preparation process is simple, the equipment is simple, and for nearly half a century, it has been used in medicine at home and abroad. Food, feed, cosmetics and other industries have been widely used. Although extrusion granulation technology has shown great advantages and has been widely used, there are still some key problems to be solved. In this paper, aiming at the problem of construction of ideal wetting mixed viscoplastic state of material suitable for extrusion round granulation, the method of combining particle preparation contrast experiment with mechanism analysis is adopted. In this paper, the mechanism of hygroscopic bonding of traditional Chinese medicine extract materials was analyzed by studying the methods of reducing viscosity and increasing viscosity of inorganic alumina. The influence of the operation parameters on the catalytic performance and apparent quality of the product during the preparation of inorganic alumina spherical catalyst carrier provides a theoretical basis for the application of extrusion and rolling granulation in a wider field. The main research work and innovative results are as follows: Basic theory research. The wetting mechanism of water and microcrystalline cellulose was analyzed. From the point of view of hydrogen bond, van der Waals force and molecular diffusion self-adhesion, the relationship between the intermolecular forces and the viscosity of the ideal wetting mixed system is discussed. The transformation mechanism of kinetic energy to surface energy in the process of fracture is analyzed and the breaking potential energy formula of the inherent relationship between the rotation number of friction chassis and material length and the breaking effect of material is derived. Through the establishment of motion model and particle force analysis model, the movement law of the whole material, the movement form of single particle and the main deformation force of the spherical particle in the process of rolling are analyzed systematically. The deformation force which plays an important role is analyzed quantitatively. To improve the drug loading level of traditional Chinese medicine extract pellets. The wetting process of water and traditional Chinese medicine extract and the wetting process of ethanol and traditional Chinese medicine extract were analyzed. The mechanism of hygroscopic bonding of traditional Chinese medicine extract was discussed from the view of coordination chemical bond, electrostatic action and hydrogen bond overassociation. Through the preparation experiment of 尾 -cyclodextrin inclusion compound, the preparation experiment of Chinese medicine Biyankang extract pellet and the development of the apparatus for viscosity determination by comparative method, the dosage of excipients in various targeted viscosity reduction methods were compared and studied. While reducing the viscosity of the system effectively, the goal of reducing the dosage of excipients is achieved. 3) the inorganic alumina powder is suitable for the construction of the viscoplastic system for extrusion round granulation. The best binder, extruder and excipient for the process of extruding round were screened out by the particle preparation experiment. Based on the analysis and application of the bonding mechanism between organic adhesive and inorganic powder particle surface, and the analysis and application of coupling agent modification mechanism, the spherical alumina based catalyst carrier was prepared. The measures to improve the roundness and strength of the product, the effects of granulation process and process parameters on the performance and apparent quality of the final product were further studied. 4) granulation practice of materials with extreme viscosity performance. In this paper, the pellet pelletizer, a patented product developed by our laboratory, is used as the main experimental equipment, the extract powder of Biyankang is the representative of high viscosity organic material, and the superfine alumina powder is the typical representative of low viscosity inorganic material. The optimum granulation formula and operation parameters were determined by particle preparation experiment, and the influence of the preparation process of spherical alumina catalyst carrier on the performance of catalyst carrier was discussed.
【学位授予单位】：华东理工大学
【学位级别】：博士
【学位授予年份】：2010
【分类号】：TQ460.62

【引证文献】