舟山海岛地区3623例儿童血清过敏原特异性IgE抗体检测结果回顾分析

发布时间：2018-04-24 07:21

本文选题：过敏原 + 免疫印迹法　；参考：《现代预防医学》2017年17期

【摘要】：目的了解舟山海岛地区儿童吸入性过敏原和食物过敏原特异性IgE抗体分布特点,为儿童过敏性疾病防治提供参考。方法以2011年8月-2016年9月在舟山医院和舟山市妇幼保健院就诊的3 623例过敏性疾病患儿为实验对象。用化学发光免疫夹心法检测血清总IgE,用欧蒙免疫印迹法检测血清过敏原特异性IgE抗体。结果 3 623例过敏性疾病患儿中,总IgE阳性(X~2165.3IU/ml)共1 520例(1 520/3 623,42.0%);检出特异性IgE抗体1 528例(1 528/3 623,42.2%);吸入性过敏原以屋尘螨/粉尘螨为主,食物过敏原以鸡蛋白和蟹为主。婴幼儿期以食物过敏原过敏为主,随着年龄增长吸入性过敏原逐渐增多,而食物过敏原逐步减少。不同季节过敏原分布存在差异,夏秋季屋尘螨/粉尘螨检出率较高(X~2=41.249,P0.01),秋冬季蟹的检出率较高(X~2=8.991,P=0.029),鸡蛋白无季节变化(X~2=3.330,P=0.344)。结论明确过敏原是预防和治疗过敏性疾病的关键,通过血清过敏原的检测能更好地为儿童过敏性疾病的病因学诊断、治疗和预防提供帮助。
[Abstract]:Objective to understand the characteristics of specific IgE antibody distribution in children with inhalation allergens and food allergen in Zhoushan Island, and to provide reference for prevention and control of allergic diseases in children. Methods 3623 children with allergic diseases in Zhoushan Hospital and Zhoushan maternal and child health care hospital in September August 2011 were tested with chemiluminescent immunization clip. Serum total IgE was detected by cardiac method, and the serum allergen specific IgE antibody was detected by immunoblotting. Results in 3623 children with allergic diseases, total IgE positive (X~2165.3IU/ml) was 1520 cases (1 520/3 623,42.0%), 1528 cases of specific IgE antibody (1 528/3 623,42.2%); inhalation allergens were mainly of dust mites / Dermatophagoides and food allergy The main food allergen was chicken protein and crab. The allergen gradually increased with age, and the food allergen gradually decreased. The distribution of allergens in different seasons was different, the detection rate of house dust mite / Dermatophagoides was higher in summer and autumn (X~2=41.249, P0.01), and the detection rate of crab in autumn and winter was higher (X~2=8.991, P=0.0). 29) there is no seasonal change in egg white (X~2=3.330, P=0.344). Conclusion it is clear that allergens are the key to prevent and treat allergic diseases. The detection of serum allergen can better provide help for the etiological diagnosis and treatment and prevention of allergic diseases in children.

【作者单位】：舟山医院检验中心;舟山市妇幼保健院检验科;
【分类号】：R725.9

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