组织工程软骨构建中不同支架材料的特征

发布时间：2018-12-19 12:33

【摘要】：背景:国内外研究认为软骨组织工程是治疗软骨缺损的新方向,目前在目前基础研究方面已取得部分进展,同时支架材料的构建在软骨组织工程中必不可少,至关重要。目的:系统回顾及总结目前软骨组织工程中不同支架材料在关节软骨缺损修复中的应用。方法:以"组织工程、支架、软骨"为中文检索词,以"tissue engineering,scaffold,cartilage"为英文检索词,应用计算机检索中国知网、维普、万方和Pub Med数据库2005年1月至2015年1月的基础研究文献,同时对文章中的参考文献进行人工检索。结果与结论:对组织工程软骨支架的选择与制备,应充分考虑到天然水凝胶材料、人工合成支架材料、复合支架材料、纳米支架材料、可注射性支架材料的优缺点。目前组织工程软骨支架材料与人体自然软骨达不到正常过渡,因此,含有过渡区域即软骨钙化层的多层一体化支架的研制将可能是今后骨软骨组织工程研究的重点之一。
[Abstract]:Background: at home and abroad, cartilage tissue engineering is considered as a new direction in the treatment of cartilage defects. At present, some progress has been made in the field of basic research, and the construction of scaffolds is essential and essential in cartilage tissue engineering. Objective: to review and summarize the application of different scaffolds in cartilage tissue engineering in the repair of articular cartilage defects. Methods: "tissue engineering, scaffold, cartilage" was used as Chinese key word and "tissue engineering,scaffold,cartilage" as English key word. The basic research documents of Wanfang and Pub Med databases from January 2005 to January 2015 are searched manually. Results & conclusion: the advantages and disadvantages of natural hydrogel material, synthetic scaffold material, composite scaffold material, nano-scaffold material and injectable scaffold material should be taken into account in the selection and preparation of tissue engineered cartilage scaffolds. At present, tissue engineering cartilage scaffolds and human natural cartilage can not achieve a normal transition, therefore, the development of multi-layer integrated scaffolds containing transitional region, that is cartilage calcification layer, may be one of the key points of bone cartilage tissue engineering research in the future.
【作者单位】：天津中医药大学研究生院;陕西省中医医院骨伤一科;天津医院创伤骨科;广州中医药大学;
【分类号】：R318.08

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