安胃汤治疗功能性消化不良寒热杂证的临床疗效观察

发布时间：2019-02-24 17:37

【摘要】：目的观察和评价安胃汤治疗功能性消化不良寒热错杂证的有效性及其对患者血浆胃动素和血清胃泌素水平的影响,为安胃汤的临床应用和科研开发提供新的依据。方法选取2015年06月至2016年06月期间在广西中医药大学附属瑞康医院消化内科住院和门诊就诊被诊断为功能性消化不良寒热错杂证的40例患者,按照随机数字表法分为治疗组和对照组,每组各20例,治疗组予服用中药安胃汤治疗,对照组予口服多潘立酮片联合复方阿嗪米特肠溶片治疗,两组患者均以2个月为1个疗程,连续治疗1个疗程后,分别分析比较两组患者的中医证候积分、临床疗效及血浆胃动素和血清胃泌素水平变化,并观察药物的安全性。结果两组患者经过1个疗程治疗后,治疗组总有效率是85.00%,对照组总有效率为75.00%,两组总有效率相比较差异具有统计学意义(P0.05);两组患者治疗后胃脘痞满、嘈杂、疼痛等主症积分和纳呆、嗳气等次症积分与治疗前相比均有所下降,以治疗组最为显著,两组相比较差异具有统计学意义(P0.05);治疗组能够显著提高患者血浆胃动素和血清胃泌素水平,与对照组相比较具有显著性差异(P0.05);两组患者在用药期间均未出现不良反应,两组相比较差异不具有统计学意义(P0.05)。结论 (1)安胃汤治疗功能性消化不良寒热错杂证临床疗效确切,安全性好,并且可以提高患者的血浆胃动素和血清胃泌素水平;(2)安胃汤治疗功能性消化不良寒热错杂证的作用机制可能与影响患者的血浆胃动素和血清胃泌素水平相关。
[Abstract]:Objective to observe and evaluate the efficacy of Anwei decoction in the treatment of functional dyspepsia with cold and heat disorder and its effect on plasma motilin and serum gastrin levels in order to provide a new basis for clinical application and scientific research of Anwei decoction. Methods from June 2015 to June 2016, 40 patients with functional dyspepsia, including cold and heat disorders, were diagnosed in the Department of Digestive Medicine, Ruikang Hospital affiliated to Guangxi University of traditional Chinese Medicine, from June 2015 to June 2016. According to the method of random number table, the treatment group was divided into treatment group (n = 20) and control group (n = 20). The treatment group was treated with Anwei decoction, and the control group was treated with oral domperidone tablet combined with compound azinomide enteric-coated tablet. Two months were used as a course of treatment. After one course of continuous treatment, the TCM syndromes scores, clinical efficacy, plasma motilin and serum gastrin levels were analyzed and compared between the two groups, and the safety of the drugs was observed. Results after one course of treatment, the total effective rate was 85.00 in the treatment group and 75.00 in the control group. The difference between the two groups was statistically significant (P0.05). After treatment, the scores of epigastric fullness, noise, pain, eructation and other major symptoms in the two groups were decreased, especially in the treatment group, and the difference was statistically significant (P0.05). The levels of plasma motilin and serum gastrin in the treatment group were significantly higher than those in the control group (P0.05). There were no adverse reactions between the two groups during the period of medication, the difference between the two groups was not statistically significant (P0.05). Conclusion (1) Anwei decoction is effective and safe in the treatment of patients with functional dyspepsia, cold and heat disorder, and can improve plasma motilin and serum gastrin levels. (2) the mechanism of Anwei decoction in treating functional dyspepsia with cold and heat disorder may be related to plasma motilin and serum gastrin level.
【作者单位】：广西中医药大学附属瑞康医院;九江市第一人民医院;广西中医药大学;
【基金】：广西中医药民族医药传承创新专项立项课题(GZLC16-17) 广西中医药民族医药自筹经费科研课题(GZZC15-19)
【分类号】：R259

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