基于关联规则的近十五年紧张型头痛中医用药规律研究

发布时间：2018-12-20 09:56

【摘要】：目的:运用关联规则分析方法挖掘和分析紧张型头痛中医用药特点及配伍规律,为临床用药提供参考,开拓用药思路。方法:搜集2000年-2014年符合纳入标准的文献中中医药治疗紧张型头痛的方剂,选用内治方剂作为数据集,运用SPSS Clementine 12.0数据挖掘软件对其药物进行关联规则分析,选用关联规则Apriori算法建立数据挖掘模型,最小支持度为10%,最小置信度为80%,并运用Web节点对药物配伍组合进行展示。结果:符合标准的治疗紧张型头痛方剂共162首,所用药物共171味,总频次2308次,使用频数在20次以上的药物共40味,共使用1646次,占药物使用总频数的71.33%。其中解表药应用频次最高,为517次,占总频次的22.40%,其后依次为:补虚药、活血化瘀药、平肝熄风药、清热药、安神药、理气药、化痰止咳平喘药、利水渗湿药、祛风湿药等。共得到符合条件的药物关联规则393条,其中包含川芎的规则最多,为282条,规则支持度大于30.00%的规则有:白芍→川芎、柴胡→川芎、当归→川芎、白芷→川芎、葛根→川芎、天麻→川芎、柴胡+白芍→川芎、当归+白芍→川芎、白芷+白芍→川芎、当归+柴胡→川芎。结论:紧张型头痛的治疗以风药为主,临床上风药与风药,风药与白芍、活血化瘀药等常相须为用。川芎为治疗紧张型头痛的要药,其配伍较为灵活。关联规则分析,可用于方剂数据库中药物配伍规律的挖掘研究,从而为临床用药提供依据和思路。
[Abstract]:Objective: to explore and analyze the characteristics and compatibility of traditional Chinese medicine (TCM) for tension headache by using association rule analysis method, to provide reference for clinical use of drugs and to develop the thinking of drug use. Methods: the prescriptions of traditional Chinese medicine (TCM) for the treatment of tension-type headache, which met the inclusion standard from 2000 to 2014, were collected. The internal prescription was selected as the data set, and the association rules of the drugs were analyzed by using SPSS Clementine 12.0 data mining software. The association rule Apriori algorithm is used to build a data mining model with a minimum support of 10 and a minimum confidence of 80. The combination of drug compatibility is demonstrated by Web node. Results: a total of 162 prescriptions were used to treat tension headache. The total frequency was 2308 times. 40 kinds of drugs were used more than 20 times, 1646 times, accounting for 71.33% of the total frequency of drug use. Among them, the antidote is the most frequently used, 517 times, accounting for 22.40 times of the total frequency, followed by: tonifying medicine, activating blood circulation and removing stasis medicine, calming the liver and eliminating wind medicine, clearing away heat medicine, tranquilizing spirit medicine, regulating qi medicine, eliminating phlegm and relieving cough and relieving asthma medicine, promoting water and seepage medicine, Antirheumatic medicine, etc. A total of 393 drug association rules were obtained, including 282 rules containing Chuanxiong, including Ligusticum lanceolata, Radix Bupleurum, Radix angelicae dahurica, Chuanxiong chuanxiong, and Radix angelicae dahuricae. Radix Puerariae, Gastrodia elata, Radix Bupleurum, Radix angelicae Alba, Radix angelicae Alba, Conclusion: the main treatment of tension headache is wind medicine, wind medicine and white peony root, promoting blood circulation and removing blood stasis. Chuanxiong for the treatment of tension headache, its compatibility is more flexible. The analysis of association rules can be used to mine the law of drug compatibility in prescription database, thus providing the basis and train of thought for clinical use of drugs.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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