Kindler syndrome protein Kindlin-1 is mainly expressed in ad

发布时间：2025-05-29 03:44

　　 Mutations of integrin-interacting protein Kindlin-1 cause Kindler syndrome and deregulation of Kindlin-1 is implicated in human cancers. The Kindlin-1-related diseases are confined in limited tissue types. However, Kindlin-1 tissue distribution and the dogma that governs Kindlin-1 expression in normal human body are elusive. This study examined Kindlin-1 expression in normal human adult organs, human and mouse embryonic organs by immunohistochemical analyses. We identified a general principle th...

【文章页数】：10 页

【文章目录】：
1 Materials and methods
    1.1 Normal and tumor tissues
    1.2 Animal experiment
    1.3 Immunohistochemistry(IHC)
2 Results
    2.1 Kindlin-1 was highly expressed in ectoderm/endoderm-derived tissues of human adults
    2.2 Kindlin-1 was highly expressed in ectoderm/endoderm-derived tissues of human embryos
    2.3 Kindlin-1 was weakly expressed in mesoderm-derived tissues of human embryos
    2.4 Kindlin-1 was highly expressed in ectoderm/endo-derm-derived but not mesoderm-derived tissues of mouse embryos
    2.5 Kindlin-1 and Kindlin-2 were conversely expressed in human tissues
3 Discussion



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